Functional_Visual

 

  


Lula Rosso
Senior Research Associate
PET modeller

Phone: +44 (0) 20 8383 3726
Facsimile: +44 (0) 20 8383 1783
E-mail: lula.rosso(at)csc.mrc.ac.uk

Education

2003, PhD Computational Chemistry, New York University, New York, USA
1998, Diploma di Laurea, Physics, Universita' "La Sapienza", Rome, Italy

Recent Honors

Selected for TANDEMplusIDEA, Sixth Framework Programme, European Commission, 2008.

Main Research Interest

Applying and developing new methodology techniques (data-processing and analysis) for the quantification of functional imaging studies, the prediction of drug distribution in vivo, the design and validation of new pharmacokinetics models and the design of imaging study protocols for new PET tracers. Her research work includes the development of computational tools for the study of PET radiotracers non-specific interactions with lipids and model membranes in collaboration with the Chemical Biological Centre, Imperial College.

Current Teaching:

3-day Experimental Design and Practical Data Analysis in PET (MRC/Imperial College).

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Publications


    PET Methodology


  • KR Gray, KB Contractor, LM Kenny, A Al-Nahhas, S Shousha, J Stebbing, HS Wasan, RC Coombes, EO Aboagye, FE Turkheimer and L. Rosso, "Kinetic filtering of [18F]Fluorothymidine in positron emission tomography studies", Physics in Medicine and Biology, [View article] (2010).

  • A Egerton, E Hirani, R Ahmad, DR Turton, D Brickute, L. Rosso, OD Howes, SK Luthra and PM Grasby, "Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: Reproducibility in tracer characteristics and characterization of extrastriatal binding.", Synapse, [View article] (2010).

  • L. Rosso, C.S. Brock, J.M. Gallo, A. Saleem, P.M. Price, F.E. Turkheimer and E.O. Aboagye, "A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients", Cancer Research, [View article] (2009).

    • Non specific binding


  • L. Rosso, A.D. Gee and I.R. Gould, "Ab initio Computational Study of Positron Emission Tomography Ligands Interacting with Lipid Molecule for the Prediction of Non-specific Binding", Journal of Computational Chemistry, [View article] (2008).


  • L. Rosso and I.R. Gould, "Structure and Dynamics of Phospholipid Bilayers using Recently Developed General All-Atom Force Fields" , Journal of Computational Chemistry, [View article] (2006).

    • Molecular dynamics


  • J. B. Abrams, L. Rosso and M. E. Tuckerman, "Efficient and precise solvation free energies via alchemical adiabatic molecular dynamics" , Journal of Chemical Physics , 125(7), Art No. 074115 (2006). [View article]


  • L. Rosso and J.B. Abrams and M.E. Tuckerman, "Mapping the backbone dihedral free energy surfaces in small peptides in solution using adiabatic free energy dynamics" , Journal of Physical Chemistry B, 109 , 4162-4167 (2005).[View article]


  • L. Rosso and M.E. Tuckerman,"Solid-state proton conduction: An ab initio molecular dynamics investigation of ammonium perchlorate doped with neutral ammonia", Pure and Applied Chemistry, 76, 49 (2004).


  • L. Rosso and M.E. Tuckerman, "Direct evidence of an anomalous charge transport mechanism in ammonium perchlorate crystal in an ammonia-rich atmosphere from first principles molecular dynamics", Solid State Ionics, 161, 219 (2003). [View article]


  • L. Rosso, P. Minary, Z. Zhu and M.E. Tuckerman, "On the use of the adiabatic molecular dynamics technique in the calculation of free energy profiles", Journal of Chemical Physics, 116, 4389 (2002). [View article]


  • L. Rosso and M.E. Tuckerman, "An adiabatic molecular  dynamics method for the calculation of free energy profiles", Molecular Simulations, 28, 91 (2002).

 

 
         

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